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Saturday, 23 February 2013
Cauliflower
Cauliflower
Are
you addicted to your gobi sabzi? If you're, it augurs well for your health.
Cauliflower or other cruciferous vegetables like broccoli protect against
cancer.
Sulforaphane — one of the primary phytochemicals in these vegetables — has been shown for the first time to selectively target and kill cancer cells while leaving normal prostate cells healthy and unaffected.
The findings, made by scientists in the Linus Pauling Institute at the Oregon State University, are another important step forward for the potential use of sulforaphone in cancer prevention and treatment.
Clinical prevention trials are under way for its use in these areas, particularly prostate and breast cancer.
It appears that sulforaphane, which is found at fairly high levels in broccoli, cauliflower and other cruciferous vegetables, is an inhibitor of histone deacetylase, or HDAC enzymes. HDAC inhibition is one of the more promising fields of cancer treatment, and is being targeted from both a pharmaceutical and dietary approach, scientists say.
"It's important to demonstrate that sulforaphane is safe if we propose to use it in cancer prevention or therapies," said Emily Ho, a principal investigator in the Linus Pauling Institute, the study's lead author.
"Just because a phytochemical or nutrient is found in food doesn't always mean its safe, and a lot can also depend on the form or levels consumed,' Ho said. "But this does appear to be a phytochemical that can selectively kill cancer cells, and that's always what you look for in cancer therapies," she added/
The findings were published in the journal "Molecular Nutrition and Food Research."
The research was supported by the National Cancer Institute and National Institute of Environmental Health Sciences.
HDACs are a family of enzymes that, among other things, affect access to DNA and play a role in whether certain genes are expressed or not, such as tumor suppressor genes.
Some of the mechanisms that help prevent inappropriate cell growth – the hallmark of cancer – are circumvented in cancer cells.
HDAC inhibitors can help "turn on' these silenced genes and restore normal cellular function.
Previous studies done with mouse models showed that prostate tumor growth was slowed by a diet containing sulforaphane.
"It is well documented that sulforaphane can target cancer cells through multiple chemopreventive mechanisms," the researchers stated in their study. "Here we show for the first time that sulforaphane selectively targets benign hyperplasia cells and cancerous prostate cells while leaving the normal prostate cells unaffected," they said.
"These findings regarding the relative safety of sulforaphane to normal tissues have significant clinical relevance as the use of sulforaphane moves towards use in human clinical trials," they added.
The results also suggest that consumption of sulforaphane-rich food are non-toxic, safe, simple and affordable.
Sulforaphane — one of the primary phytochemicals in these vegetables — has been shown for the first time to selectively target and kill cancer cells while leaving normal prostate cells healthy and unaffected.
The findings, made by scientists in the Linus Pauling Institute at the Oregon State University, are another important step forward for the potential use of sulforaphone in cancer prevention and treatment.
Clinical prevention trials are under way for its use in these areas, particularly prostate and breast cancer.
It appears that sulforaphane, which is found at fairly high levels in broccoli, cauliflower and other cruciferous vegetables, is an inhibitor of histone deacetylase, or HDAC enzymes. HDAC inhibition is one of the more promising fields of cancer treatment, and is being targeted from both a pharmaceutical and dietary approach, scientists say.
"It's important to demonstrate that sulforaphane is safe if we propose to use it in cancer prevention or therapies," said Emily Ho, a principal investigator in the Linus Pauling Institute, the study's lead author.
"Just because a phytochemical or nutrient is found in food doesn't always mean its safe, and a lot can also depend on the form or levels consumed,' Ho said. "But this does appear to be a phytochemical that can selectively kill cancer cells, and that's always what you look for in cancer therapies," she added/
The findings were published in the journal "Molecular Nutrition and Food Research."
The research was supported by the National Cancer Institute and National Institute of Environmental Health Sciences.
HDACs are a family of enzymes that, among other things, affect access to DNA and play a role in whether certain genes are expressed or not, such as tumor suppressor genes.
Some of the mechanisms that help prevent inappropriate cell growth – the hallmark of cancer – are circumvented in cancer cells.
HDAC inhibitors can help "turn on' these silenced genes and restore normal cellular function.
Previous studies done with mouse models showed that prostate tumor growth was slowed by a diet containing sulforaphane.
"It is well documented that sulforaphane can target cancer cells through multiple chemopreventive mechanisms," the researchers stated in their study. "Here we show for the first time that sulforaphane selectively targets benign hyperplasia cells and cancerous prostate cells while leaving the normal prostate cells unaffected," they said.
"These findings regarding the relative safety of sulforaphane to normal tissues have significant clinical relevance as the use of sulforaphane moves towards use in human clinical trials," they added.
The results also suggest that consumption of sulforaphane-rich food are non-toxic, safe, simple and affordable.
Nature cure Ashram founded by Mahatma Gandhi
Nature cure Ashram founded by Mahatma Gandhi
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Saturday, 9 February 2013
7 Warning Signs Of A Heart Attack
7 Warning Signs Of A Heart Attack
Here are 7 signs that can be taken as warning
and could help avert a catastrophic situation:
1. Discomfort in the Chest
The most
common warning sign of a heart attack is the feeling of discomfort or heaviness
in the chest. This feeling could also be more of a burning sensation. Any of
these symptoms should not be taken lightly, and if it occurs more than once,
you need to rush to your doctor. If another person is complaining of the
problem, chances are they have experienced the feeling before and are only
expressing it now. So, rush them to the nearest doctor or hospital immediately
for a check up.
2. Shortness of Breath
If your
breathing gets heavy and the breath falls short even after a short walk, climb or other form of
movement or exercise, it should be a huge cause of worry. Even if this
condition is not accompanied with chest discomfort, it should be taken as a
warning sign.
3. Sweating
Whilst sweating is inevitable in the scorching heat of May and June, excessive
sweating even in cool conditions is uncalled for. If you notice such sweating,
consult a medical professional immediately.
4. Nausea
Regularly
feeling nauseous of dizzy could imply the onset of a heart attack. Do not treat
is callously as a sign of tiredness. This could happen due to the artery
getting blocked. It could also display itself via excessive stress, fatigue
after short spans of movement or exercise, or a feeling of weakness despite eating
and sleeping well.
5. Numbness in Arms
If your
arms feel numb and seem to be drifting to the sides, heart problem may be the
cause.
6. Unresponsiveness
If
certain parts of your body begin to stop responding, do not ignore the
circumstance. The affected parts may be the shoulders, arms or back of the
neck.
7. Slurring while Speaking
Difficulty
while speaking need not necessarily occur after a bout of drinking with the
buddies. It could be a graver situation than that! Inability to speak
coherently could be the sign of a great attack. If you think you are suffering
this ask a friend or relative to help by asking them to understand what you are
saying.
A heart
attack can be avoided if the warning signs are read correctly and in time. Seek
medical aid immediately if one or more of the above symptoms are noticed. They
could be the result of a choked artery. Even if heart attack is not the result,
a check up should definitely not be avoided! Take care!
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